TY - BOOK TI - Organic Chemistry SN - 9780198503460 U1 - 547 PY - 2001/// CY - New York PB - Oxford University press N1 - Note continued: 39. Determining reaction mechanisms -- There are mechanisms and there are mechanisms -- Determining reaction mechanisms: the Cannizzaro reaction -- Be sure of the structure of the product -- Systematic structural variation -- The Hammett relationship -- Other kinetic evidence for reaction mechanisms -- Acid and base catalysis -- The detection of intermediates -- Stereochemistry and mechanism -- Summary of methods for the investigation of mechanism -- Further reading -- 40. Organometallic chemistry -- Transition metals extend the range of organic reactions -- The 18 electron rule -- Bonding and reactions in transition metal complexes -- Palladium is the most widely used metal in homogeneous catalysis -- The Heck reaction couples together an organic halide or triflate and an alkene -- Cross-coupling of organometallics and halides -- Allylic electrophiles are activated by palladium(O) -- Palladium-catalysed amination of aromatic rings -- Alkenes coordinated to palladium(II) are attacked by nucleophiles -- Palladium catalysis in the total synthesis of a natural alkaloid -- An overview of some other transition metals -- Further reading -- 41. Asymmetric synthesis -- Nature is asymmetric -- The chiral pool: Nature's chiral centres `off the shelf' -- Resolution can be used to separate enantiomers -- Chiral auxiliaries -- Chiral reagents -- Asymmetric catalysis -- Asymmetric formation of carbon-carbon bonds -- Asymmetric aldol reactions -- Enzymes as catalysts -- Further reading -- 42. Organic chemistry of life -- Primary metabolism -- Life begins with nucleic acids -- Proteins are made of amino acids -- Sugars -- just energy sources? -- Lipids -- Mechanisms in biological chemistry -- Natural products -- Fatty acids and other polyketides are made from acetyl CoA -- Terpenes are volatile constituents of plants -- Further reading -- 43. Organic chemistry today -- Science advances through interaction between disciplines -- Chemistry vs viruses -- The future of organic chemistry -- Further reading ER -