TY - BOOK AU - Gray, Jeffrey A. TI - The neuropsychology of anxiety U1 - 157.3 PY - 2003/// CY - Oxford PB - OUP N1 - 1 OVERVIEW Scarting points for the neuropsychology of anxiety Fear versus anxiety The hierarchical defence system The amygdala The septo-hippocampal system What is the septo-hippocampal system? What does the septo-hippocampal system do? A common computational core for septo-hippocampal function—Mark 1 A common computational core for septo-hippocampal function—Mark 2 The role of other brain regions Conclusion 2 ETHOLOGY AND ANXIETY Ethoexperimental analysis Ethopharmacologicai analysis The ethology and ethopharmacology of anxiety and fear Some terminological problems 3 LEARNING THEORY AND ANXIETY Two-process theories of learning Elicited reactions in learning experiments The behavioural inhibition system revisited Conclusions 4 THE ANXIOLYTIC DRUGS What are the anxiolytic drugs? Clinical usage The classical anxiolytics Buspirone, ipsapirone Clomipramine and obsessive-compulsive disorder Beta-blockers Clinical actions of the anxiolytics—a summary Bridging the species gap The behavioural effects of anxiolytic drugs in animals Anxiolytic action—some conclusions 5 A THEORY OF THE BEHAVIOURAL INHIBITION SYSTEM Evolution, anxiety, and rules of thumb—the search for the behavioural inhibition system Behavioural inhibition and rules of thumb 6 THE NEUROLOGY OF ANXIETY The periaqueductal grey, fight, flight, and freezing The medial hypothalamus and escape The amygdala The defence system—integration Interim conclusions Comparison between the septal, hippocampal, and anxiolytic syndromes The effects of lesions of the noradrenergic and scrotonergic systems The cholinergic system The prefrontal cortex and cingulate cortex The prefrontal cortex The cingulate cortex Overview of prefrontal and cingulate cortex Prefrontal and cingulate cortex and anxiety Conclusions 7 HIPPOCAMPAL PLACE FIELDS Single-unit responses: non-spatial tasks Single-unit responses: correlations with spatial position The relation between spatial fields and head direction fields Space, discrimination, classical conditioning, and habituation Path integration Topographic mapping of single cell fields Conclusion i MEMORY AND THE SEPTO-HIPPOCAMPAL SYSTEM Human versus animal amnesia The hippocampus as the crucial site for amnesic deficits Types of memory The effects of delay The role of context A preliminary theory of hippocampal amnesia Relational memory Configural memory Semantic encoding Recognition memory Working memory Temporal buffer Spatial memory Interference: some initial comments The role of the hippocampal formation in memory 9 FUNDAMENTALS OF THE SEPTO-HIPPOCAMPAL SYSTEM Anxiolytics and the septo-hippocampal system—an overview The defence system The motor/working memory system The 'emotion' system General approach to the septo-hippocampal system The anatomy of the septo-hippocampal system Long-term memory Role of the septo-hippocampal system in sensory processing The mismatch detection system Aminergic gating systems Theta activity Conclusion 10 A THEORY OF THE SEPTO-HIPPOCAMPAL SYSTEM The theory: some basic assumptions The theory: architecture The theory: mechanism Some scenarios The theta rhythm Conclusion 11 SYMPTOMS AND SYNDROMES OF ANXIETY Cognitive effects of anxiolytic drugs Anxiolytic action and the amygdala Humpty Dumpty had a great fall Anxiolytic action and the neocorte The clinical psychology of anxiety Behavioural aspects of anxiety syndromes Cognitive aspects of anxiety syndromes Physiological aspects of anxiety syndromes The theory of anxiety Clinical anxiety and memory A functional typology for defence Panic disorder Specific phobia Post-traumatic stress disorder Agoraphobia Social phobia Generalized anxiety disorder Obsessive—compulsive disorder A typology of the anxiety-related disorders Differential diagnosis Conclusion 12 PUTTING HUMPTY DUMPTY TOGETHER AGAIN: THE ANXIOUS PERSONALITY AND ITS INHERITANCE The anxious personality Neuroticism vs. trait anxiety The genetics of neuroticism and emotionality 13 THE TREATMENT OF ANXIETY Behaviour therapy Drug therapy Cognitive-behavioural therapy Coda ER -