TY  - BOOK
AU  - Bezerianos,Anastasios
AU  - Dragomir,Andrei
AU  - Balomenos,Panos
TI  - Computational Methods for Processing and Analysis of Biological Pathways
T2  - SpringerBriefs in Computer Science,
SN  - 9783319538686
AV  - QH324.2-324.25 
U1  - 570.285 23
PY  - 2017///
CY  - Cham
PB  - Springer International Publishing, Imprint: Springer
KW  - Bioinformatics
KW  - Systems biology
KW  - Computational Biology/Bioinformatics
KW  - Systems Biology
N1  - Introduction -- Networks and Pathways in Systems Pharmacology -- Time Varying Methods for Pathway and Sub-Pathway Analysis -- Identification of Differentially Expressed Pathways and Sub-Pathways
N2  - This work offers a guided walkthrough of one of the most promising research areas in modern life sciences, enabling a deeper understanding of involved concepts and methodologies via an interdisciplinary view, focusing on both well-established approaches and cutting-edge research. Highlighting what pathway analysis can offer to both the experimentalist and the modeler, the text opens with an introduction to a general methodology that outlines common workflows shared by several methods. This is followed by a review of pathway and sub-pathway based approaches for systems pharmacology. The work then presents an overview of pathway analysis methods developed to model the temporal aspects of drug- or disease-induced perturbations and extract relevant dynamic themes. The text concludes by discussing several state-of-the-art methods in pathway analysis, which address the important problem of identifying differentially expressed pathways and sub-pathways
UR  - https://doi.org/10.1007/978-3-319-53868-6
ER  -