TY  - BOOK
AU  - Lindon,John C.,ed
AU  - Nicholson,Jeremy K.,ed
AU  - Holmes,Elaine,ed
ED  - ScienceDirect (Online service)
TI  - The handbook of metabonomics and metabolomics
SN  - 9780444528414
U1  - 572.4  
PY  - 2007///
CY  - Amsterdam, Boston
PB  - Elsevier
KW  - Molecular biology
KW  - Technique
KW  - Biochemistry
KW  - Gene expression
KW  - Metabolism
KW  - Molecular genetics
KW  - Biomolecules
KW  - Molecular Biology
KW  - methods
KW  - Gene Expression
N1  - Includes bibliographical references and index; Front Cover --  The Handbook of Metabonomics and Metabolomics -- Copyright Page; Table of Contents; Foreword --  Preface -- Chapter 1 Metabonomics and Metabolomics Techniques and Their Applications in Mammalian Systems -- 1.1. Metabonomics and metabolomics in relation to other "omics" approaches -- 1.2. The concept of global systems biology -- 1.3. Interactions between host and other genomes --  1.4. Time-scales of "-omics" events --  1.5. Samples for metabonomics and metabolomics --  1.6. Analytical technologies --  1.7. Chemometric methods; 1.8. New approaches to biomarker identification using chemometrics -- 1.9. Standardisation of metabolic experiments and their reporting1.10. Overview of applications of metabonomics and metabolomics to mammalian systems --  1.11. Concluding remarks --  References; Chapter 2 Cellular Metabolomics -- The Quest for Pathway Structure; 2.1. Introduction --  2.2. How large is the metabolome? --  2.3. Metabolite identification --  2.4. Pathway identification --  2.5. "Omics" data integration; 2.6. Metabolic fluxes; 2.7. Metabolic networks; Acknowledgments; References; Chapter 3 NMR Spectroscopy Techniques for Application to Metabonomics; 3.1. Introduction; 3.2. Principles of NMR -- 3.3. Hardware requirements and automation -- 3.4. Sample handling --  3.5. NMR Experiments and their processing --  3.6. Data pre-processing --  3.7. Outlook; References --  Chapter 4 High-Resolution Magic Angle Spinning NMR Spectroscopy --  4.1. Introduction; 4.2. Nuclear spin Hamiltonian; 4.3. Coherence averaging by magic angle spinning; 4.4. MAS NMR experiments; 4.5. Pulse sequences; 4.6. Applications --  Acknowledgements; References --  Chapter 5 Chromatographic and Electrophoretic Separations Combined with Mass Spectrometry for Metabonomics; Abstract; 5.1. Introduction; 5.2. Gas Chromatography-Mass Spectrometry -- 5.3. Liquid Chromatography-Mass Spectrometry5.4. HPLC-MS for metabonomics --  5.5. Capillary LC-MS; 5.6. Ultra performance Liquid Chromatography-Mass Spectrometry --  5.7. Capillary zone electrophoresis-Mass Spectrometry --  5.8. GC-, LC- and CE-MS for metabonomics --  A perspective --  5.9. Conclusions --  References --  Chapter 6 Chemometrics Techniques for Metabonomics --  6.1. Introduction --  6.2. Chemometric approaches to metabonomic studies --  6.3. Summary -- 6.4. Extensions and future outlook; References; Chapter 7 Non-linear Methods for the Analysis of Metabolic Profiles; 7.1. Introduction -- 7.2. Unsupervised methods7.3. Supervised methods --  7.4. Other methods --  7.5. Conclusions --  Acknowledgements --  References --  Chapter 8 Databases and Standardisation of Reporting Methods for Metabolic Studies --  8.1. Introduction: The challenges --  8.2. Tackling the challenges; 8.3. Standards in action - a working example; 8.4. Final remarks --  References; Chapter 9 Metabonomics in Preclinical Pharmaceutical Discovery and Development; 9.1. Introduction; 9.2. Background; 9.3. Methods --  9.4. Preclinical efficacy --  9.5. Preclinical toxicity --  9.6. Conclusions; References -- Chapter 10 Applications of Metabonomics in Clinical Pharmaceutical R&D

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