TY - BOOK AU - Satyanarayanajois,Seetharama D.,ed TI - Drug design and discovery: methods and protocols SN - 9781617790119 (alk. paper) U1 - 615.19 PY - 2011/// CY - New York PB - Humana Press KW - Drug development KW - Drug Design KW - Drug Discovery KW - Molecular Biology KW - methods N1 - Includes bibliographical references and index; 1. Virtual Screening for Lead Discovery Yat T. Tang and Garland R. Marshall 2. Computer-Aided Drug Discovery and Development Shuxing Zhang 3. Using Active Site Mapping and Receptor-Based Pharmacophore Tools: Prelude to Docking and De Novo/Fragment-Based Ligand Design Ashutosh Tripathi, J. Andrew Surface, and Glen E. Kellogg 4. Methods for Evaluation of Structural and Biological Properties of Anti-Invasive Natural Products Mudit Mudit, Mohammad Khanfar, Girish V. Shah, and Khalid A. El Sayed 5. Solid-Phase Peptide Synthesis Using Microwave Irradiation Justin K. Murray, Jennifer Aral, and Les P. Miranda 6. Fluorescent and Lanthanide Labeling for Ligand Screens, Assays, and Imaging Jatinder S. Josan, Channa R. De Silva, Byunghee Yoo, Ronald M. Lynch, Mark D. Pagel, Josef Vagner, and Victor J. Hruby 7. DNA-Directed Assembly Microarray for Protein and Small Molecule Inhibitor Screening Ng Jin Kiat, Fritz Simeon, Too Heng Phon, and Parayil Kumaran Ajikumar 8. Selection of Peptide Ligands for Human Placental Transcytosis Systems Using In vitro Phage Display Saleem Basha, Shruthi Vaidhyanathan, and Giovanni M. Pauletti 9. Optimization of the Tetrazolium Dye (MTT) Colorimetric Assay for Cellular Growth and Viability Paul W. Sylvester 10. Imaging NF- B Signaling in Mice for Screening Anti-Cancer Drugs Delira Robbins and Yunfeng Zhao 11. Evaluation of Anticancer Agents Using Flow Cytometry Analysis of Cancer Stem Cells Vineet Gupta, Qian-Jin Zhang, and Yong-Yu Liu 12. Chemical Screening with Zebrafish Embryos Hanbing Zhong and Shuo Lin 13. iTRAQTM Labeling Coupled with LC-MALDI Mass Spectrometry for Monitoring Temporal Response of Colorectal Cancer Cells to Butyrate Treatment Hwee Tong Tan, Teck Kwang Lim, Maxey C.M. Chung, and Qingsong Lin 14. Heterotypic Cell Adhesion Assay for the Study of Cell Adhesion Inhibition Seetharama D. Satyanarayanajois, Sharon Ronald, and Jining Liu 15. Evaluation of Antibacterial Activity of Proteins and Peptides Using a Specific Animal Model for Wound Healing Ramar Perumal Samy, Maung Maung Thwin, Vincent T.K.Chow, Ho Bow, and Ponnampalam Gopalakrishnakone 16. In vitro Immunogenicity Risk Assessment of Therapeutic Proteins in Preclinical Setting Puneet Gaitonde and Sathy V. Balu-Iyer ER -