Design and analysis of animal studies in pharmaceutical development/
edited by Shein-Chung Chow, Jen-pei Liu
- 1st ed.
- New York: Marcel Dekker, 1998.
- 407 p.
1. Introduction / Shein-Chung Chow and Jen-pei Liu -- 2. Experimental Design Principles for Animal Studies in Pharmaceutical Development / Walter W. Piegorsch and A. John Bailer -- 3. Interval Estimation with Small Samples for Median Lethal Dose or Median Effective Dose / Keith A. Soper -- 4. Principles in Statistical Testing in Randomized Toxicological Studies / Ludwig A. Hothorn and Dieter Hauschke -- 5. Subchronic Toxicity Studies / Steven Bailey -- 6. Safety Assessment in Toxicological Studies: Proof of Safety Versus Proof of Hazard / Dieter Hauschke and Ludwig A. Hothorn -- 7. The Design of Long-Term Carcinogenicity Studies / R. John Weaver and Marshall N. Brunden -- 8. Analysis of Long-Term Carcinogenicity Studies / Hongshik Ahn and Ralph L. Kodell -- 9. Design of Developmental and Reproductive Toxicology Studies / R. John Weaver and Marshall N. Brunden -- 10. Analysis of Reproductive and Developmental Studies / James J. Chen -- 11. The In Vitro Ames Tests / Wherly P. Hoffman -- 12. The In Vitro Chinese Hamster Ovary Cell Mutagenesis Studies / Jen-pei Liu and Shein-Chung Chow