Workbook for organic synthesis: strategy and control/ Paul Wyatt and Stuart Warren

Preface. A: Introduction: Selectivity. 1. Planning Organic Syntheses: Tactics, Strategy and Control. 2. Chemoselectivity. 3. Regioselectivity: Controlled Aldol Reactions. 4. Stereoselectivity: Stereoselective Aldol Reactions. 5. Alternative Strategies for Enone Synthesis. 6. Choosing a Strategy: The Synthesis of Cyclopentenones. B: Making Carbon-Carbon Bonds. 7. The Ortho Strategy for Aromatic Compounds. 8. delta-Complexes of Metals. 9. Controlling the Michael Reaction. 10. Specific Enol Equivalents. 11. Extended Enolates. 12. Allyl Anions. 13. Homoenolates. 14. Acyl Anion Equivalents. C: Carbon-Carbon Double Bonds. 15. Synthesis of Double Bonds of Defined Stereochemistry. 16. Vinyl Anions. 17. Electrophilic Attack on Alkenes. 18. Vinyl Cations. 19. Allyl Alcohols: Allyl Cation Equivalents (and More). D: Stereochemistry. 20. Control of Stereochemistry - Introduction. 21. Diastereoselectivity. 22. Resolution . 23. The Chiral Pool: Asymmetric Synthesis with Natural Products as Starting Materials. 24. Asymmetric Induction I: Reagent-Based Strategy. 25. Asymmetric Induction II: Asymmetric Catalysis: Formation of C-O and C-N Bonds. 26. Asymmetric Induction III: Asymmetric Catalysis: Formation of C-H and C-C Bonds. 27. Asymmetric Induction IV: Substrate-Based Strategy. 28. Kinetic Resolution. 29. Enzymes: Biological Methods in Asymmetric Synthesis. 30. New Chiral Centres from Old: Enantiomerically Pure Compounds & Sophisticated Syntheses. 31. Strategy of Asymmetric Synthesis. E: Functional Group Strategy. 32. Functionalisation of Pyridine. 33. Oxidation of Aromatic Rings and of Enol(ate)s. 34. Functionality and Pericyclic Reactions: Nitrogen Heterocycles by Cycloadditions and Sigmatropic Rearrangements. 35. Synthesis and Chemistry of Azoles and other Heterocycles with Two or more Heteroatoms. 36. Tandem Organic Reactions. Index.