Genetics/ Snustad,D. Peter

Chapter 1 The Science Of Genetics. The Personal Genome. An Invitation. Three Great Milestones In Genetics. DNA As The Genetic Material. Genetics And Evolution. Levels Of Genetic Analysis. Genetics In The World: Applications Of Genetics To Human Endeavors. Chapter 2. Cellular Reproduction. Cells And Chromosomes. Mitosis. Meiosis. Life Cycles Of Some Model Genetic Organisms. Chapter 3 Mendelism: The Basic Principles Of Inheritance. Mendel's Study Of Heredity. Applications Of Mendel's Principles. Testing Genetic Hypotheses. Mendelian Principles In Human Genetics. Chapter 4 Extensions Of Mendelism. Allelic Variation And Gene Function. Gene Action: From Genotype To Phenotype. Inbreeding: Another Look At Pedigrees. Chapter 5 The Chromosomal Basis Of Mendelism. Chromosomes. The Chromosome Theory Of Heredity. Sex-Linked Genes In Humans. Sex Chromosomes And Sex Determination. Dosage Compensation Of X-Linked Genes. Chapter 6 Variation In Chromosome Number And Structure. Cytological Techniques. Polyploidy. Aneuploidy. Rearrangements Of Chromosome Structure. Chapter 7 Linkage, Crossing Over, And Chromosome Mapping In Eukaryotes. Chromosome Mapping. Cytogenetic Mapping. Linkage Analysis In Humans. Recombination And Evolution. Chapter 8 The Genetics Of Bacteria And Their Viruses. Multi-Drug-Resistant Bacteria: A Ticking Timebomb? Viruses And Bacteria In Genetics. The Genetics Of Viruses. The Genetics Of Bacteria. Mechanisms Of Genetic Exchange In Bacteria. The Evolutionary Significance Of Genetic Exchange In Bacteria. Chapter 9 DNA And The Molecular Structure Of Chromosomes. Functions Of The Genetic Material. Proof That Genetic Information Is Stored In DNA. Proof That RNA Stores The Genetic Information In Some Viruses. Chromosome Structure In Prokaryotes And Viruses. Chromosome Structure In Eukaryotes. Chapter 10 Replication Of DNA And Chromosomes. Basic Features Of DNA Replication In Vivo. DNA Replication In Prokaryotes. Unique Aspects Of Eukaryotic Chromosome Replication. Chapter 11 Transcription And RNA Processing. Transfer Of Genetic Information: The Central Dogma. The Process Of Gene Expression. Transcription In Prokaryotes. Transcription And RNA Processing In Eukaryotes. Interrupted Genes In Eukaryotes: Exons And Introns. Removal Of Intron Sequences By RNA Splicing. Chapter 12 Translation and the Genetic Code Protein Structure One Gene One Colinear Polypeptide Protein Synthesis: Translation The Genetic Code Codon-tRNA Interactions Chapter 13 Mutation, DNA Repair, and Recombination Mutation: Source of the Genetic Variability Required for Evolution The Molecular Basis of Mutation Mutation: Basic Features of the Process Mutation: Phenotypic Effects Assigning Mutations to Genes by the Complementation Test Screening Chemicals for Mutagenicity: The Ames Test DNA Repair Mechanisms Inherited Human Diseases with Defects in DNA Repair DNA Recombination Mechanisms Chapter 14 The Techniques of Molecular Genetics Basic Techniques Used to Identify, Amplify, and Clone Genes Construction and Screening of DNA Libraries The Molecular Analysis of DNA, RNA, and Protein The Molecular Analysis of Genes and Chromosomes Chapter 15 Genomics Genomics: An Overview Correlated Genetic, Cytological, and Physical Maps of Chromosomes Map Position-Based Cloning of Genes The Human Genome Project RNA and Protein Assays of Genome Function Comparative Genomics Chapter 16 Applications of Molecular Genetics Use of Recombinant DNA Technology to Identify Human Genes and Diagnose Human Diseases Molecular Diagnosis of Human Diseases Human Gene Therapy DNA Profiling Production of Eukaryotic Proteins in Bacteria Transgenic Plants and Animals Reverse Genetics: Dissecting Biological Processes by Inhibiting Gene Expression Chapter 17 Transposable Genetic Elements Transposable Elements: An Overview Transposable Elements in Bacteria Cut-and-Paste Transposons in Eukaryotes Retroviruses and Retrotransposons Transposable Elements in Humans The Genetic and Evolutionary Significance of Transposable Elements Chapter 18 Regulation of Gene Expression in Prokaryotes Constitutive, Inducible, and Repressible Gene Expression Positive and Negative Control of Gene Expression Operons: Coordinately Regulated Units of Gene Expression The Lactose Operon in E. coli: Induction and Catabolite Repression The Tryptophan Operon in E. coli: Repression and Attenuation Translational Control of Gene Expression Posttranslational Regulatory Mechanisms Chapter 19 Regulation of Gene Expression in Eukaryotes Ways of Regulating Eukaryotic Gene Expression: An Overview Induction of Transcriptional Activity by Environmental and Biological Factors Molecular Control of Transcription in Eukaryotes Posttranscriptional Regulation of Gene Expression by RNA Interference Gene Expression and Chromatin Organization Activation and Inactivation of Whole Chromosomes Chapter 20 The Genetic Control of Animal Development A Genetic Perspective on Development Maternal Gene Activity in Development Genetic Analysis of Development in Vertebrates Chapter 21 The Genetic Basis of Cancer Cancer: A Genetic Disease Oncogenes Tumor Suppressor Genes Genetic Pathways to Cancer Chapter 22 Inheritance of Complex Traits Complex Traits Statistics of Quantitative Genetics Analysis of Quantitative Traits Correlations Between Relatives Quantitative Genetics of Human Behavioral Traits Chapter 23 Population Genetics The Theory of Allele Frequencies Natural Selection Random Genetic Drift Populations in Genetic Equilibrium Chapter 24 Evolutionary Genetics The Emergence of Evolutionary Theory Genetic Variation in Natural Populations Molecular Evolution Speciation Human Evolution Appendices Appendix A: The Rules of Probability Appendix B: Binomial Probabilities Appendix C: In Situ Hybridization Appendix D: Evidence for an Unstable Messenger RNA Appendix E: Evolutionary Rates Answers to Odd-Numbered Questions and Problems Glossary Photo Credits Illustration Credits Index