Bioinorganic chemistry : inorganic elements in the chemistry of life: an introduction and guide/ (Record no. 185309)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 10377nam a2200217Ia 4500 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 0470975237 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CUS |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 572.51 |
| Item number | KAI/B |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Kaim, Wolfgang trans. |
| 245 #0 - TITLE STATEMENT | |
| Title | Bioinorganic chemistry : inorganic elements in the chemistry of life: an introduction and guide/ |
| Statement of responsibility, etc. | Written and translated by Wolfgang Kaim, Brigitte Schwederski, Axel Klein |
| 250 ## - EDITION STATEMENT | |
| Edition statement | 2nd. ed. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc. | UK : |
| Name of publisher, distributor, etc. | Wiley, |
| Date of publication, distribution, etc. | 2013. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | xvi,409p. : |
| Other physical details | ill. ; |
| Dimensions | 25cm. |
| 440 ## - SERIES | |
| Title | Inorganic chemistry. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc | Includes references and index. |
| 505 ## - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 1 Historical Background, Current Relevance and Perspectives 1<br/><br/>References 6<br/><br/>2 Some General Principles 7<br/><br/>2.1 Occurrence and Availability of Inorganic Elements in Organisms 7<br/><br/>Insertion: The Chelate Effect 14<br/><br/>Insertion: “Hard” and “Soft” Coordination Centers 14<br/><br/>2.2 Biological Functions of Inorganic Elements 14<br/><br/>2.3 Biological Ligands for Metal Ions 16<br/><br/>2.3.1 Coordination by Proteins: Comments on Enzymatic Catalysis 17<br/><br/>Insertion: The “Entatic State” in Enzymatic Catalysis 20<br/><br/>2.3.2 Tetrapyrrole Ligands and Other Macrocycles 22<br/><br/>Insertion: Electron Spin States in Transition Metal Ions 28<br/><br/>2.3.3 Nucleobases, Nucleotides and Nucleic Acids (RNA, DNA) as Ligands 31<br/><br/>Insertion: Secondary Bonding 32<br/><br/>2.4 Relevance of Model Compounds 34<br/><br/>References 34<br/><br/>3 Cobalamins, Including Vitamin and Coenzyme B12 37<br/><br/>3.1 History and Structural Characterization 37<br/><br/>Insertion: Bioorganometallics I [1] 38<br/><br/>3.2 General Reactions of Alkylcobalamins 41<br/><br/>3.2.1 One-electron Reduction and Oxidation 41<br/><br/>3.2.2 Co–C Bond Cleavage 42<br/><br/>Insertion: Electron Paramagnetic Resonance I 43<br/><br/>3.3 Enzyme Functions of Cobalamins 45<br/><br/>3.3.1 Adenosylcobalamin (AdoCbl)-dependent Isomerases 45<br/><br/>Insertion: Organic Redox Coenzymes 48<br/><br/>3.3.2 Alkylation Reactions of Methylcobalamin (MeCbl)-dependent Alkyl Transferases 51<br/><br/>3.4 Model Systems and the Enzymatic Activation of the Co–C Bond 52<br/><br/>References 53<br/><br/>4 Metals at the Center of Photosynthesis: Magnesium and Manganese 57<br/><br/>4.1 Volume and Efficiency of Photosynthesis 57<br/><br/>4.2 Primary Processes in Photosynthesis 59<br/><br/>4.2.1 Light Absorption (Energy Acquisition) 59<br/><br/>4.2.2 Exciton Transport (Directed Energy Transfer) 59<br/><br/>4.2.3 Charge Separation and Electron Transport 62<br/><br/>Insertion: Structure Determination by X-ray Diffraction 62<br/><br/>4.3 Manganese-catalyzed Oxidation of Water to O2 68<br/><br/>Insertion: Spin–Spin Coupling 73<br/><br/>References 75<br/><br/>5 The Dioxygen Molecule, O2: Uptake, Transport and Storage of an Inorganic Natural Product 77<br/><br/>5.1 Molecular and Chemical Properties of Dioxygen, O2 77<br/><br/>5.2 Oxygen Transport and Storage through Hemoglobin and Myoglobin 82<br/><br/>5.3 Alternative Oxygen Transport in Some Lower Animals: Hemerythrin and Hemocyanin 92<br/><br/>5.3.1 Magnetism 92<br/><br/>5.3.2 Light Absorption 93<br/><br/>5.3.3 Vibrational Spectroscopy 93<br/><br/>Insertion: Resonance Raman Spectroscopy 93<br/><br/>5.3.4 Móssbauer Spectroscopy 94<br/><br/>Insertion: Móssbauer Spectroscopy 94<br/><br/>5.3.5 Structure 95<br/><br/>5.4 Conclusion 96<br/><br/>References 96<br/><br/>6 Catalysis through Hemoproteins: Electron Transfer, Oxygen Activation and Metabolism of Inorganic Intermediates 99<br/><br/>6.1 Cytochromes 101<br/><br/>6.2 Cytochrome P-450: Oxygen Transfer from O2 to Nonactivated Substrates 103<br/><br/>6.3 Peroxidases: Detoxification and Utilization of Doubly Reduced Dioxygen 108<br/><br/>6.4 Controlling the Reaction Mechanism of the Oxyheme Group: Generation and Function of Organic Free Radicals 110<br/><br/>6.5 Hemoproteins in the Catalytic Transformation of Partially Reduced Nitrogen and Sulfur Compounds 112<br/><br/>Insertion: Gasotransmitters 113<br/><br/>References 114<br/><br/>7 Iron–Sulfur and Other Non-heme Iron Proteins 117<br/><br/>7.1 Biological Relevance of the Element Combination Iron–Sulfur 117<br/><br/>Insertion: Extremophiles and Bioinorganic Chemistry 118<br/><br/>7.2 Rubredoxins 122<br/><br/>7.3 [2Fe-2S] Centers 122<br/><br/>7.4 Polynuclear Fe/S Clusters: Relevance of the Protein Environment and Catalytic Activity 123<br/><br/>7.5 Model Systems for Fe/S Proteins 128<br/><br/>7.6 Iron-containing Enzymes without Porphyrin or Sulfide Ligands 130<br/><br/>7.6.1 Iron-containing Ribonucleotide Reductase 130<br/><br/>7.6.2 Soluble Methane Monooxygenase 132<br/><br/>7.6.3 Purple Acid Phosphatases (Fe/Fe and Fe/Zn) 133<br/><br/>7.6.4 Mononuclear Non-heme Iron Enzymes 133<br/><br/>References 135<br/><br/>8 Uptake, Transport and Storage of an Essential Element, as Exemplified by Iron 139<br/><br/>Insertion: Metallome 139<br/><br/>8.1 The Problem of Iron Mobilization: Oxidation States, Solubility and Medical Relevance 140<br/><br/>8.2 Siderophores: Iron Uptake by Microorganisms 141<br/><br/>Insertion: Optical Isomerism in Octahedral Complexes 144<br/><br/>8.3 Phytosiderophores: Iron Uptake by Plants 149<br/><br/>8.4 Transport and Storage of Iron 150<br/><br/>8.4.1 Transferrin 152<br/><br/>8.4.2 Ferritin 155<br/><br/>8.4.3 Hemosiderin 159<br/><br/>References 160<br/><br/>9 Nickel-containing Enzymes: The Remarkable Career of a Long-overlooked Biometal 163<br/><br/>9.1 Overview 163<br/><br/>9.2 Urease 164<br/><br/>9.3 Hydrogenases 166<br/><br/>9.4 CO Dehydrogenase = CO Oxidoreductase = Acetyl-CoA Synthase 169<br/><br/>9.5 Methyl-coenzyme M Reductase (Including the F430 Cofactor) 172<br/><br/>Insertion: Natural and Artificial (Industrial) C1 Chemistry 174<br/><br/>Insertion: Bioorganometallics II: The Organometallic Chemistry of Cobalt and Nickel 176<br/><br/>9.6 Superoxide Dismutase 177<br/><br/>9.7 Model Compounds 178<br/><br/>Further Reading 178<br/><br/>References 179<br/><br/>10 Copper-containing Proteins: An Alternative to Biological Iron 183<br/><br/>10.1 Type 1: “Blue” Copper Centers 186<br/><br/>Insertion: Electron Paramagnetic Resonance II 187<br/><br/>10.2 Type 2 and Type 3 Copper Centers in O2-activating Proteins: Oxygen Transport and Oxygenation 191<br/><br/>10.3 Copper Proteins as Oxidases/Reductases 195<br/><br/>10.4 Cytochrome c Oxidase 200<br/><br/>10.5 Cu,Zn- and Other Superoxide Dismutases: Substrate-specific Antioxidants 203<br/><br/>References 207<br/><br/>11 Biological Functions of the “Early” Transition Metals: Molybdenum, Tungsten, Vanadium and Chromium 211<br/><br/>11.1 Oxygen Transfer through Tungsten- and Molybdenum-containing Enzymes 211<br/><br/>11.1.1 Overview 211<br/><br/>11.1.2 Oxotransferase Enzymes Containing the Molybdopterin or Tungstopterin Cofactor 213<br/><br/>Insertion: “Oxidation” 214<br/><br/>11.2 Metalloenzymes in the Biological Nitrogen Cycle: Molybdenum-dependent Nitrogen Fixation 219<br/><br/>11.3 Alternative Nitrogenases 226<br/><br/>11.4 Biological Vanadium Outside of Nitrogenases 229<br/><br/>11.5 Chromium(III) in the Metabolism? 231<br/><br/>References 232<br/><br/>12 Zinc: Structural and Gene-regulatory Functions and the Enzymatic Catalysis of Hydrolysis and Condensation Reactions 235<br/><br/>12.1 Overview 235<br/><br/>12.2 Carboanhydrase 238<br/><br/>12.3 Carboxypeptidase A and Other Hydrolases 243<br/><br/>12.4 Catalysis of Condensation Reactions by Zinc-containing Enzymes 248<br/><br/>12.5 Alcohol Dehydrogenase and Related Enzymes 249<br/><br/>12.6 The “Zinc Finger” and Other Gene-regulatory Zinc Proteins 251<br/><br/>12.7 Insulin, hGH, Metallothionein and DNA Repair Systems as Zinc-containing Proteins 253<br/><br/>References 254<br/><br/>13 Unequally Distributed Electrolytes: Function and Transport of Alkali and Alkaline Earth Metal Cations 257<br/><br/>13.1 Characterization and Biological Roles of K+, Na+, Ca2+ and Mg2+ 257<br/><br/>Insertion: Heteroatom Nuclear Magnetic Resonance 262<br/><br/>13.2 Complexes of Alkali and Alkaline Earth Metal Ions with Macrocycles 264<br/><br/>13.3 Ion Channels 267<br/><br/>13.4 Ion Pumps 270<br/><br/>Further Reading 273<br/><br/>References 273<br/><br/>14 Catalysis and Regulation of Bioenergetic Processes by the Alkaline Earth Metal Ions Mg2+ and Ca2+ 277<br/><br/>14.1 Magnesium: Catalysis of Phosphate Transfer by Divalent Ions 277<br/><br/>14.2 The Ubiquitous Regulatory Role of Ca2+ 283<br/><br/>Further Reading 291<br/><br/>References 291<br/><br/>15 Biomineralization: The Controlled Assembly of “Advanced Materials” in Biology 295<br/><br/>15.1 Overview 295<br/><br/>15.2 Nucleation and Crystal Growth 299<br/><br/>Insertion: Dimensions 300<br/><br/>15.3 Examples of Biominerals 301<br/><br/>15.3.1 Calcium Phosphate in the Bones of Vertebrates and the Global P Cycle 301<br/><br/>Insertion: The Global P Cycle 305<br/><br/>15.3.2 Calcium Carbonate and the Global Inorganic C Cycle 306<br/><br/>Insertion: The Global C Cycle and the Marine Inorganic C Cycle 307<br/><br/>15.3.3 Amorphous Silica 308<br/><br/>15.3.4 Iron Biominerals 309<br/><br/>15.3.5 Strontium and Barium Sulfates 310<br/><br/>15.4 Biomimetic Materials 310<br/><br/>Further Reading 311<br/><br/>References 311<br/><br/>16 Biological Functions of the Nonmetallic Inorganic Elements 315<br/><br/>16.1 Overview 315<br/><br/>16.2 Boron 315<br/><br/>16.3 Silicon 315<br/><br/>16.4 Arsenic and Trivalent Phosphorus 316<br/><br/>16.5 Bromine 317<br/><br/>16.6 Fluorine 317<br/><br/>16.7 Iodine 318<br/><br/>16.8 Selenium 320<br/><br/>References 324<br/><br/>17 The Bioinorganic Chemistry of the Quintessentially Toxic Metals 327<br/><br/>17.1 Overview 327<br/><br/>17.2 Lead 329<br/><br/>17.3 Cadmium 332<br/><br/>17.4 Thallium 334<br/><br/>17.5 Mercury 335<br/><br/>17.6 Aluminum 340<br/><br/>17.7 Beryllium 342<br/><br/>17.8 Chromium and Tungsten 343<br/><br/>17.9 Toxicity of Nanomaterials 344<br/><br/>Further Reading 345<br/><br/>References 345<br/><br/>18 Biochemical Behavior of Radionuclides and Medical Imaging Using Inorganic Compounds 349<br/><br/>18.1 Radiation Risks and Medical Benefits from Natural and Synthetic Radionuclides 349<br/><br/>18.1.1 The Biochemical Impact of Ionizing Radiation from Radioactive Isotopes 349<br/><br/>18.1.2 Natural and Synthetic Radioisotopes 350<br/><br/>18.1.3 Bioinorganic Chemistry of Radionuclides 351<br/><br/>Insertion: Fukushima Daiichi, Chernobyl, Hiroshima and Nuclear Weapons Testing 353<br/><br/>18.1.4 Radiopharmaceuticals 356<br/><br/>18.1.5 Technetium: A “Synthetic Bioinorganic Element” 359<br/><br/>18.1.6 Radiotracers for the Investigation of the Metallome 362<br/><br/>18.2 Medical Imaging Based on Nonradioactive Inorganic Compounds 362<br/><br/>18.2.1 Magnetic Resonance Imaging 362<br/><br/>18.2.2 X-ray Contrast Agents 364<br/><br/>Further Reading 364<br/><br/>References 365<br/><br/>19 Chemotherapy Involving Nonessential Elements 369<br/><br/>19.1 Overview 369<br/><br/>19.2 Platinum Complexes in Cancer Therapy 369<br/><br/>19.2.1 Discovery, Application and Structure–Effect Relationships 369<br/><br/>19.2.2 Cisplatin: Mode of Action 372<br/><br/>19.3 New Anticancer Drugs Based on Transition Metal Complexes 378<br/><br/>19.3.1 Overview and Aims for Drug Development 378<br/><br/>19.3.2 Nonplatinum Anticancer Drugs 379<br/><br/>19.4 Further Inorganic Compounds in (Noncancer) Chemotherapy 383<br/><br/>19.4.1 Gold-containing Drugs Used in the Therapy of Rheumatoid Arthritis 383<br/><br/>19.4.2 Lithium in Psychopharmacologic Drugs 384<br/><br/>19.4.3 Bismuth Compounds against Ulcers 385<br/><br/>19.4.4 Vanadium-containing Insulin Mimetics and V-containing Anti-HIV Drugs 386<br/><br/>19.4.5 Sodium Nitroprusside 386<br/><br/>19.5 Bioorganometallic Chemistry of Nonessential Elements 387 |
| 650 ## - SUBJECT | |
| Keyword | Bioinorganic chemistry. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Schwederski, Brigitte trans. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Klein, Axel trans. |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | General Books |
| Withdrawn status | Lost status | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Full call number | Accession number | Date last seen | Date last checked out | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Central Library, Sikkim University | Central Library, Sikkim University | General Book Section | 29/08/2016 | 572.51 KAI/B | P40321 | 10/06/2023 | 17/05/2023 | General Books |