Modified nucleosides: in biochemistry, biotechnology, and medicine/ (Record no. 169559)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01464cam a22003977a 4500 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783527318209 (alk. paper) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 3527318208 (alk. paper) |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | CUS |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 572.85 |
| Item number | HER/M |
| 245 00 - TITLE STATEMENT | |
| Title | Modified nucleosides: in biochemistry, biotechnology, and medicine/ |
| Statement of responsibility, etc. | edited by Piet Herdewijn. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc. | Weinheim : |
| Name of publisher, distributor, etc. | Wiley-VCH, |
| Date of publication, distribution, etc. | c2008. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | xxvi, 658 p. : |
| Other physical details | ill. (some col.) ; |
| Dimensions | 25 cm. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc | Includes bibliographical references and index. |
| 505 ## - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Modified Nucleosides; Contents; Preface; List of Contributors; Part I Biochemistry and Biophysics; 1 Investigations on Fluorine-Labeled Ribonucleic Acids by (19)F NMR Spectroscopy; 1.1 Introduction; 1.1.1 NMR Spectroscopic Properties of the (19)F Nucleus; 1.1.1.1 General NMR Spectroscopic Properties; 1.1.1.2 (19)F versus (1)H NMR Spectroscopy; 1.1.1.3 Factors Affecting the (19)F Chemical Shift in Biomolecules; 1.1.1.4 Fluorine Relaxation in Biological Systems; 1.1.1.5 Solvent-Induced Isotope Shifts of (19)F NMR Resonances; 1.1.2 (19)F NMR Spectroscopy of Proteins 1.1.2.1 Incorporation of Fluorinated Amino Acids into Proteins1.1.2.2 (19)F NMR Spectroscopic Studies of Proteins; 1.2 (19)F NMR Spectroscopy of Nucleic Acids; 1.2.1 Nucleic Acids with Fluorinated Nucleobases; 1.2.1.1 Transfer RNAs; 1.2.1.2 HhaI Methyltransferase in Complex with DNA Duplexes; 1.2.1.3 Minimal Hammerhead Ribozyme; 1.2.1.4 HIV TAR RNA; 1.2.2 Nucleic Acids with Fluorinated Ribose Units; 1.2.2.1 R1inv RNA; 1.2.2.2 RNA Secondary Structure Equilibria; 1.2.2.3 RNA Ligand Binding; 1.2.3 Influence of Fluorine Modifications on Nucleic Acid Structure; 1.3 Conclusions; References 2 8-Oxo-7,8-Dihydro-2 ́-Deoxyguanosine: A Major DNA Oxidation Product2.1 Introduction; 2.2 Formation of 8-Oxo-7,8-Dihydroguanine; 2.2.1 Single Lesion; 2.2.1.1 ·OH Radical; 2.2.1.2 One-Electron Oxidation; 2.2.1.3 Singlet Oxygen; 2.2.2 Tandem Lesions; 2.3 Reactivity of 8-Oxo-7,8-Dihydro-2 ́-Deoxyguanosine; 2.3.1 One-Electron Oxidation; 2.3.1.1 Secondary Oxidation Products; 2.3.1.2 DNA-Protein Crosslinks; 2.3.2 Singlet Oxygen; 2.3.2.1 Nucleoside; 2.3.2.2 Oligonucleotide; 2.4 Formation of 8-Oxo-7,8-Dihydro-2 ́-Deoxyguanosine in Cellular DNA; 2.4.1 Methods of Measurement 2.4.1.1 HPLC Methods (HPLC-ECD and HPLC-MS/MS)2.4.1.2 Enzymic Assays; 2.4.2 Indirect Effects of Ionizing Radiation (·OH Radical); 2.4.3 High-Intensity UV Laser Irradiation (One-Electron Oxidation); 2.4.4 UVA Photosensitization ((1)O(2)); 2.5 Synthesis of 8-OxodGuo and Insertion into Oligonucleotides; 2.6 Conclusions; References; 3 Modified DNA Bases: Probing Base-Pair Recognition by Polymerases; 3.1 Introduction; 3.1.1 The Importance of Understanding DNA Polymerases; 3.1.2 The Utility of Modified Nucleobases in Probing Mechanisms; 3.1.3 The Scope of this Chapter 3.2 Basic Principles and Methods in Replication3.2.1 The Chemistry of Polymerases; 3.2.2 Different Classes of Polymerases; 3.2.3 Methods Used in Polymerase Studies; 3.3 Alternative Hydrogen-Bonding Schemes; 3.3.1 Thioguanine-Pyridone; 3.3.2 Benner Hydrogen-Bonding Variants; 3.4 Non-Polar Nucleoside Isosteres; 3.4.1 The Concept of Nucleobase Isosteres; 3.4.2 Synthesis, Structure, and Physical Properties; 3.4.3 Base-Pairing Properties; 3.4.4 Polymerase Behavior; 3.4.5 Other Classes of Polymerases; 3.4.6 Summary of Watson-Crick H-Bonding Effects in Polymerase Active Sites 3.5 Non-Polar Steric Probes<br/> |
| 650 #0 - SUBJECT | |
| Keyword | Nucleosides |
| General subdivision | Synthesis. |
| 650 #0 - SUBJECT | |
| Keyword | Nucleosides |
| General subdivision | Therapeutic use. |
| 650 12 - SUBJECT | |
| Keyword | Nucleosides |
| General subdivision | chemistry. |
| 650 12 - SUBJECT | |
| Keyword | Nucleosides |
| General subdivision | physiology. |
| 650 22 - SUBJECT | |
| Keyword | Antibiotics, Antineoplastic |
| General subdivision | therapeutic use. |
| 650 22 - SUBJECT | |
| Keyword | Antiviral Agents |
| General subdivision | therapeutic use. |
| 650 22 - SUBJECT | |
| Keyword | Nucleosides |
| General subdivision | therapeutic use. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Herdewijn, Piet., ed. |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | General Books Science Library |
| Withdrawn status | Lost status | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Full call number | Accession number | Date last seen | Date last checked out | Koha item type | Public note |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Science Library, Sikkim University | Science Library, Sikkim University | Science Library General Section | 29/08/2016 | 572.85 HER/M | P24530 | 16/01/2020 | 18/03/2019 | General Books Science Library | Books For SU Science Library |